脓毒症及分子机制相关研究

个人简介 湖南省儿童医院儿科医学研究所副主任、科研转化中心（产业办）副主任（主持工作），博士毕业于中南大学湘雅三医院，专业免疫学。聚焦脓毒症、弥散性血管内凝血等危重症机制研究，主持国自然青年基金、省自然科学基金等项目，以独立一作、通讯作者在 JCR一区、二区期刊发表多篇高水平论文，参与发表《Immunity》《Nature Communications》等顶刊。 代表性论文 1. Xiangyu Wang* et al.KLF7-IT1-ARPC2 Axis in Macrophages Orchestrates Caspase-4-Driven Hypercoagulation in Sepsis. 2. Jinpeng，Gan*,Xiangyu Wang# and Xiulan Lu# Development and Validation of a LASSO-Logistic Regression Model for Predicting DIC in Pediatric HLH. 3. Xiangyu Wang*; Zhaozheng Li; Yang Bai; Rui Zhang; Ran Meng; Fangping Chen; Haichao Wang; Timothy R Billiar; Timothy R Billiar; Ben Lu; Yiting Tang ; A small molecule binding HMGB1 inhibits caspase-11 mediated lethality in sepsis, Cell Death Dis, 2021, 12(4): 402 4.Xiangyu Wang*; Jian Shi; Zhaozheng Li; Ling Li; Rui Zhang; Yang Bai; Junmei Li; Fang Liang; Yiting Tang ; A 8-hydroxy-quinoline derivative protects against Lipopolysaccharide-induced lethality in endotoxemia by inhibiting HMGB1-mediated Caspase-11- signaling, Front Ph